ChemInform Abstract: Synthetic Approaches to 4,8-Dimethyl-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens and 4,8-Dimethyl-5′-(N-aminomethyl)-4′,5′-dihydropsoralens

Autor:	Jeffrey D. Laskin, Christophe Guillon, Whittemore Marilyn S, Ned D. Heindel, Ivan Jabin, Thomas E. Mcneel, Diane E. Heck, Robert D. Rapp
Rok vydání:	2010
Předmět:	Chemistry Electrophile Organic chemistry General Medicine Psoralen ultraviolet a Ring (chemistry) Combinatorial chemistry
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200152214
Popis:	New synthetic approaches to 4,8-dimethyl-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens and 4,8-dimemyl-5′-(N-aminomethyl)-4′,5′-dihydropsoralens are described. The 5′-halomethyl-4′,5′-dihydro-psoralen precursors are formed by electrophilic ring closures of 4,8-dimethyl-6-allyl-7-hydroxycoumarin. The ring-closure reactions may also be applied to the synthesis of 5′-halomethyl-4-methyl-4′,5′-dihydroangelicins. The compounds are potential therapeutic agents for improved psoralen ultraviolet A radiation treatment.
Databáze:	OpenAIRE
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