Experimental warfarin poisoning in the dog
| Autor: | C. Thomson, C. D. Forbes, A.D. McEwan, Colin R. M. Prentice, G. P. McNicol |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Prothrombin time
medicine.medical_specialty General Veterinary medicine.diagnostic_test Factor VII business.industry medicine.medical_treatment Pathology and Forensic Medicine chemistry.chemical_compound Endocrinology Coagulation chemistry Bleeding time Internal medicine Anesthesia Hemostasis Fibrinolysis Euglobulin lysis time medicine business Blood coagulation test |
| Zdroj: | Journal of Comparative Pathology. 83:173-180 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/0021-9975(73)90040-6 |
| Popis: | Experimental warfarin poisoning in dogs produced a profound haemostatic defect with depression in the levels of factors II, VII, IX and X and gross prolongation of the bleeding time. Surprisingly platelet function was unaltered suggesting that in the dog the intrinsic coagulation pathway plays an important part in the normal bleeding time. There was slight shortening of the euglobulin lysis time, but no other changes in the components of the fibrinolytic enzyme system. Rapid reversal of the clotting abnormality was produced by the intravenous injection of vitamin K1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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