Aromatase Inhibitor Versus Clomiphene Citrate for Induction of Ovulation in Unexplained Infertility
| Autor: | Fahd A. El-Omda, Ebtesam M.A. Saeed, Mahmoud M.H. El-Tohamy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gynecology
Infertility medicine.medical_specialty 030219 obstetrics & reproductive medicine Aromatase inhibitor medicine.drug_class business.industry medicine.medical_treatment Letrozole media_common.quotation_subject Female infertility medicine.disease 03 medical and health sciences Pregnancy rate 0302 clinical medicine medicine Ovulation induction 030212 general & internal medicine business Ovulation Unexplained infertility medicine.drug media_common |
| Zdroj: | Al-Azhar Medical Journal. 49:677-686 |
| ISSN: | 1110-0400 |
| Popis: | Background: Infertility is the inability of a sexually active couple with no contraception to achieve natural pregnancy within one year. Unexplained female infertility should be a term used when the female reproductive system has been evaluated according to current agreed standards, and no abnormalities are detected. Clomiphene citrate (CC) has been used as a first-line ovulation induction agent. Aromatase inhibitors are new groups of drugs for fertility treatment. Letrozole is an orally-active aromatase inhibitor, with good potential for ovulation induction. Objective: This study compared the effect of clomiphene citrate and letrozole in induction of ovulation in the treatment of infertility. Patients and methods: This prospective randomized controlled study was conducted at Obstetrics and Gynecology Department, Al-AzharUniversityHospitals and Al-AhrarHospital (ministry of health) on 100 women between 20 - 35 years old having unexplained infertility. Patients were divided into two equal groups: Letrozole group received 5 mg of letrozole orally daily from day 3 to day 7 of menses, and CC group, women received 100 mg of clomiphene citrate orally once daily from day 3 to day 7 of the menses and for up to three menstrual cycles. Results: There was a significant increase of positive pregnancy test in letrozole group compared to clomiphene group.There was a significant difference in multiple pregnancy rate and high significant differences in Doppler flow indices between letrozole group and clomiphene group. Conclusion:Letrozole has a better ovulation rate with better follicular development and higher pregnancy rate, CC group has less effect on the endometrial thickness and side effects. |
| Databáze: | OpenAIRE |
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