Counterfeit Adderall Containing Aceclofenac from Internet Pharmacies
| Autor: | Maria Cristina Gaudiano, Eleonora Antoniella, Luisa Valvo, Anna Borioni |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Injury control Quantitative nmr Accident prevention Chemistry 010401 analytical chemistry Poison control Carbon-13 NMR Mass spectrometry 01 natural sciences 0104 chemical sciences Pathology and Forensic Medicine Rapid identification 03 medical and health sciences 0302 clinical medicine Genetics medicine Aceclofenac 030212 general & internal medicine medicine.drug |
| Zdroj: | Journal of Forensic Sciences. 61:1126-1130 |
| ISSN: | 0022-1198 |
| DOI: | 10.1111/1556-4029.13095 |
| Popis: | A nontargeted approach based on liquid chromatography equipped with a quadrupole time-of-flight mass detector (LC-MS Q-TOF) joined to nuclear magnetic resonance (NMR) analysis allowed rapid identification and quantification of the anti-inflammatory drug aceclofenac in illegal Adderall tablets. The largest chromatographic peak had m/z = 354.030 and m/z = 376.012 matching, respectively, the ionic structures (M + H)(+) and (M + Na)(+) of a molecule M. The accurate mass data generated the molecular formula C16 H13 Cl2 NO4. A screening of the pharmaceutical active substances having that molecular formula together with the MS/MS fragmentation pattern suggested aceclofenac. Aceclofenac structure was unambiguously confirmed by (1) H and (13) C NMR experiments. The aceclofenac content was 90 mg/tablet (RSD 2%) as detected by quantitative NMR. Information on the identity and content of illegal drugs is required for legal purposes; it supports in evaluating the effective impact on users safety, and it is useful for control laboratories using a targeted approach in their analytical activities.© 2016 American Academy of Forensic Sciences. Language: en |
| Databáze: | OpenAIRE |
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