1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites

Autor:	Stephen A. Espitia, Eckard Weber, John F. W. Keana, Jon E. Hawkinson, Richard M. Woodward, Victor I. Ilyin, Hua Zheng
Rok vydání:	1996
Předmět:	Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Drug Discovery Glycine Pharmaceutical Science Molecular Medicine NMDA receptor Antagonism Molecular Biology Biochemistry
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:439-440
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00036-4
Popis:	A series of 1-hydroxy-1,4-dihydroquinoxaline-2,3-diones was synthesized and assayed for NMDA receptor glycine site antagonism. Except for 4a, these were found to be 3–80 times weaker antagonists than the analogous 1,4-dihydroquinoxaline-2,3-diones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11d9879a1d967ace8bf1b6608cea21f2 https://doi.org/10.1016/0960-894x(96)00036-4 Zobrazit plný text záznamu Full Text from ScienceDirect