Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19)
| Autor: | Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Bröer, Volker Vallon |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | American Journal of Physiology-Renal Physiology. 323:F455-F467 |
| ISSN: | 1522-1466 1931-857X |
| Popis: | Based on insights from studies manipulating glucose transport, the hypothesis has been proposed that inhibiting intestinal uptake or renal reabsorption of energy substrates has unique therapeutic potential to improve metabolic disease and kidney outcome in response to injury. The present study takes this idea to B0AT1, the major transporter for neutral amino acids in the intestine and kidney, and shows that its absence attenuates aristolochic acid-induced nephropathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|