A general synthesis of (2Z)-terpenoic acids

Autor: Jean-Marie Poirier, Dominique Cahard, Malika Mammeri, Lucette Duhamel
Rok vydání: 2000
Předmět:
Zdroj: Tetrahedron Letters. 41:3619-3622
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00457-3
Popis: A three-step synthesis of (2 Z ), (4 E )-polyenic acids 6 is described. Condensation of aldehydes 1 with potassium prenal enolate led to dihydropyranols 3 which were oxidized into dihydropyrones 5 , precursors of (2 Z) , (4 E )-polyenic acids 6 . The procedure was applied to a synthesis of 13- cis -retinoic acids from β-ionylidene acetaldehydes.
Databáze: OpenAIRE