New intravesical instillation therapy for urinary fungi infections with a preparation using amphotericin B emulsion in hydroxypropylcellulosum

Autor:	Kiyoyuki Tsurusaki, Nobuyasu Nishisaka, Tatuo Iseki, Masaaki Tsujita, M Umeda, Sigeru Tanabe, Ryoji Yasumoto, Mtsanobu Maekawa, Asakawa M, Kakinoki K, Tanaka S
Rok vydání:	1989
Předmět:	business.industry Amphotericin B Anesthesia Urinary system Intravesical instillation medicine Pharmaceutical Science Urinary concentration business Adverse effect medicine.drug Urethral catheter
Zdroj:	Drug Delivery System. 4:12-14
ISSN:	1881-2732 0913-5006
DOI:	10.2745/dds.4.12
Popis:	New intravesical instillation therapy was performed in eleven patients with urinary fungi infection. Anti-fungal agent(HPC-Am)was made by emulsing 50 mg of amphotericin B(Am)in 15 ml hydroxypropylcellulosum(HPC). HPC-Am was given intravesically through a urethral catheter and retained for approximate an hour. A clinical relief of manifestation with absence of fugi was subsequently obtained in 9 out of 11 patients. After intravesical administration just one time, effective urinary concentration of Am against the fungi was continued for the longast period of 6 consecutive days. There was no adverse reaction of this therpy. These findings suggest that HPC-Am therapy shows more clinical effect rather than conventional Am instillation.
Databáze:	OpenAIRE
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