Molecular structure of pancuronium bromide (3α,17β-diacetoxy-2β,16β-dipiperidino-5α-androstane dimethobromide), a neuromuscular blocking agent. Crystal and molecular structure of the water: methylene chloride solvate

Autor:	George Ferguson, Christine Hannaway, D. S. Savage, I. R. Mackay, A. F. Cameron
Rok vydání:	1971
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Organic Chemistry Pancuronium bromide Iodide Medicinal chemistry Chloride chemistry.chemical_compound Molecular geometry medicine Molecule Orthorhombic crystal system Androstane Physical and Theoretical Chemistry Methylene medicine.drug
Zdroj:	J. Chem. Soc. B. :410-415
ISSN:	0045-6470
DOI:	10.1039/j29710000410
Popis:	The crystal and molecular structure of pancuronium bromide (3α,17β-diacetoxy-2β,16β-dipiperidino-5α-androstane dimethobromide), a potent neuromuscular blocking agent, has been determined by a single-crystal X-ray analysis. The compound crystallises in the orthorhombic system, space group P212121, with four molecules of [C35H60N2O4]2+ 2Br–, four molecules of methylene chloride, and four molecules of water in a unit cell of dimensions a= 11·10, b= 13·99, and c= 26·07 A. As part of a study of cholinergic transmission systems, the molecular geometry has been compared with the geometries of acetylcholine bromide and lactoylcholine iodide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11cf76978367cb2a67f184ee8fc52abf https://doi.org/10.1039/j29710000410 Zobrazit plný text záznamu