Stereoselective Olefination Reactions Promoted by Rieke Manganese
| Autor: | Jose M. Concellon, Humberto Rodriguez‐Solla, Vicente del Amo, Pamela Diaz |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Synthesis. 2009:2634-2645 |
| ISSN: | 1437-210X 0039-7881 |
| Popis: | A study of the advantages of using manganese, an inexpensive and nontoxic metal, to perform stereoselective β-elimination reactions and to promote sequential olefination reactions of aldehydes to obtain α,β-unsaturated esters and amides is presented. Various elimination reactions, all of them characterized by occurring with complete stereoselectivity and in high yields, were performed using active manganese (Mn*) as metalating agent. This ability of manganese has been applied to develop a novel and direct synthesis of (E)-α,β-unsaturated esters or amides and (Z)-α,β-unsaturated α-halo esters and α-choroamides through a Mn * -mediated sequential olefination protocol of aldehydes with dichloro esters or amides and trihalo esters or trichloroamides, respectively. |
| Databáze: | OpenAIRE |
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