Reaction of o-Aminobenzamides with Dialkyl Carbonates and Ionic Liquids: A Novel one-pot, High-yield, Microwave-assisted Synthesis of 1-Alkylquinazoline-2,4-diones

Autor:	Ignacio A. Rivero, R Leticia Guerrero
Rok vydání:	2017
Předmět:	010405 organic chemistry General Chemistry Alkylation 01 natural sciences Microwave assisted 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Yield (chemistry) Microwave irradiation Ionic liquid Organic chemistry Microwave
Zdroj:	Journal of the Mexican Chemical Society. 56
ISSN:	2594-0317 1870-249X
DOI:	10.29356/jmcs.v56i2.322
Popis:	A simple and efficient methodology for the synthesis of 1-alkyl-2,4-(1H,3H)-quinazolinediones from o-aminobenzamides has been developed. The novel one-pot cyclization-alkylation reactions are easier and faster than any other reported protocols and resulted in excellent yields (96-98%) and high purities, making this methodology suitable for library synthesis in drug discovery efforts. By applying microwave irradiation at 130 °C and in the presence of ionic liquids, dimethyl or diethyl carbonates simultaneously act as carbonylating and alkylating agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11c1bd99eba0ea7186bea026bd79e579 https://doi.org/10.29356/jmcs.v56i2.322 Zobrazit plný text záznamu