Molecular Characterization of a Novel Chromosomal Translocation in a Case of Acute Myeloid Leukemia Transformed From Myeloproliferative Neoplasm**

Autor:	Chandrika Sreekantaiah, Dipti Gheewala, Craig Devoe, Nayyara Mahmood, Silvat Sheikh-Fayyaz, Xinmin Zhang, Gokul Kandala, Hua Guo, Judith Brody
Rok vydání:	2015
Předmět:	Genetics biology Myeloid leukemia Myeloproliferative disease Chromosomal translocation General Medicine medicine.disease Fusion gene Ubiquitin hemic and lymphatic diseases biology.protein Cancer research medicine Gene Myeloproliferative neoplasm
Zdroj:	American Journal of Clinical Pathology. 144:A149-A149
ISSN:	1943-7722 0002-9173
Popis:	Chromosomal band 11q13 has been reported to be a common site of aberrations in hematologic malignancies. However, only a few genes have been reported. We identified a novel t(11;14)(q13;q32) translocation in an acute myeloid leukemia (AML) case transforming from myeloproliferative neoplasm (MPN), which resulted in a novel fusion gene rearrangement involving PELI3 (Pellino3). Pellino3 is a member of the E3 ubiquitin ligases. Over-expression …
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11c0a9a38a231392f9a6c3ef841bdd62 https://doi.org/10.1093/ajcp/144.suppl2.149 Zobrazit plný text záznamu