Pharmacological evaluation of the dichloromethanol extract fromInula crithmoides L

Autor:	E. Primo Yúfera, Juan V. Esplugues, M D Barrachina, I. Sanz, R. Bello
Rok vydání:	1995
Předmět:	Pharmacology Inula biology Analgesic Biological activity biology.organism_classification Acute toxicity chemistry.chemical_compound chemistry In vivo Anesthesia Toxicity medicine Histamine Acetylcholine medicine.drug
Zdroj:	Phytotherapy Research. 9:294-298
ISSN:	1099-1573 0951-418X
DOI:	10.1002/ptr.2650090412
Popis:	The pharmacological effect of the dichloromethanol extract of Inula crithmoides L. was analysed in in vitro and in vivo models. The extract dose-dependently decreased arterial blood pressure and furthermore it showed low acute toxicity, CNS depressor activity and analgesic and antiinflammatory effects. Preincubation of the guinea-pig ileum and rat duodenum (100 μg/mL) produced a significant reduction in the contractile effects of histamine and acetylcholine and a concentration-related inhibition of the effects of serotonin. Following further fractionation the methylene chloride/acetone (50/50) fraction caused a significant decrease in motor activity and significantly reduced the threshold of pain chemical stimulus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11bf3c4c91bc8cd41bfe67e94e23f82f https://doi.org/10.1002/ptr.2650090412 Zobrazit plný text záznamu Plný text