A study on dose response of NIPAM-based dosimeter used in radiotherapy
| Autor: | Yuan-Jen Chang, Hsieh Ling-Ling, Bor-Tsung Hsieh, Jay Wu, C. J. Chang, Ruo-Ping Han |
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| Rok vydání: | 2011 |
| Předmět: |
Dosimeter
food.ingredient Chromatography Health Toxicology and Mutagenesis Tetrakis(hydroxymethyl)phosphonium chloride Public Health Environmental and Occupational Health Pollution Gelatin Analytical Chemistry Dose–response relationship chemistry.chemical_compound Monomer food Nuclear Energy and Engineering chemistry Radiology Nuclear Medicine and imaging Irradiation Polymer gel Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 290:141-148 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-011-1161-4 |
| Popis: | The newly manufactured N-isopropylacrylamide (NIPAM) polymer gel is composed of four components, i.e., gelatin, monomer (NIPAM), crosslinker (N,N’-methylenebisacrylamide, Bis), and antioxidant (tetrakis hydroxymethyl phosphonium chloride, THPC). In this study, we investigated the effects of gel composition on the dose response of NIPAM polymer gel. A statistical experiment to analyze the contribution of each composition to the linearity and sensitivity of NIPAM gel was performed. Results indicate that the amount of gelatin, NIPAM (15.17%), Bis, and THPC have dominant effects on the sensitivity of the gel, with contributions of 59.73, 15.17, 10.64, and 14.45%, respectively. The amount of gelatin and Bis mainly affected the linearity of the gel, with contributions of 44.70 and 50.99%, respectively. The linearity of most compositions of the gel was greater than 0.99 when (%C)/(%T) was lower than 8.0. Optimal (%C)/(%T) for higher sensitivity should be in the range of 4−9. The temporal stability experiment showed that the dose response curve attained stability at about 5 h after irradiation and persisted up to 3 months. |
| Databáze: | OpenAIRE |
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