Effects of tumor growth on interleukins and circulating immune complexes. Mechanisms of immune unresponsiveness

Autor: Stephen J. Lahey, Glenn Steele, Mary L. Rodrick, T. S. Ravikumar, Donald S. Ross, Richard E. Wilson, Vincent King, Dorothy Wright, Alelia E. Munroe
Rok vydání: 1984
Předmět:
Zdroj: Cancer. 53:1373-1378
ISSN: 1097-0142
0008-543X
1373-1378
DOI: 10.1002/1097-0142(19840315)53:6<1373::aid-cncr2820530626>3.0.co;2-b
Popis: This study delineates the temporal relationship between immune complex formation and tumor growth, and provides one possible explanation for host immunosuppression during tumor growth. The authors have studied serial circulating immune complex (CIC) levels and interleukin (IL) elaboration by peripheral blood cells (IL-1 production by adherent mononuclear cells [AMC]; and IL-2 generation by peripheral blood mononuclear cells [PBMC]) during the growth of syngeneic tumor isografts in an inbred rat model. Male Wistar/Furth (W/Fu) rats were injected, subcutaneously (SC) with 2 × 106 W163 (a dimethylhydrazine [DMH]-induced colon adenocarcinoma) cells into their hind limbs. Serial CIC levels, (measured by the antigen nonspecific polyethylene glycol turbidity assay) and IL-1 and IL-2 production were measured before isografting and weekly thereafter. Progressive local tumor growth occurred for 3 weeks followed by regional lymph node metastases during the fourth week. During local tumor growth, there was a progressive rise in CIC levels (123% rise compared with baseline value; P < 0.05) which correlated with a fall in both IL-1 and IL-2 generation (r = −0.768). At the time of regional metastasis, the mean CIC levels declined, and there was a further significant decrease in IL production (IL-1 = 0.9% and IL-2 = 10% of controls in tumor bearers). These results show that progressive tumor growth results in decreased IL production by host PBC, and suggest that CIC may be involved in regulating IL generation. Cancer 53:1373-1378, 1984.
Databáze: OpenAIRE
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