A convenient route to chiral γ-lactones via asymmetric hydrogenation of γ-ketoesters using the RuCl3–BINAP–HCl catalytic system

Autor:	Marina I. Struchkova, V. A. Ferapontov, L. S. Gorshkova, O. V. Turova, Maxim G. Vinogradov, E. V. Starodubtseva
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Asymmetric hydrogenation Enantioselective synthesis Organic chemistry Biochemistry Catalysis BINAP
Zdroj:	Tetrahedron. 64:11713-11717
ISSN:	0040-4020
DOI:	10.1016/j.tet.2008.10.012
Popis:	A convenient one-step synthesis of chiral γ-lactones has been performed. The method is based on enantioselective hydrogenation of γ-ketoesters using the RuCl 3 –BINAP–HCl catalytic system. Chiral γ-lactones (91–99% ee) have been isolated in 57–88% yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11b2c889f21df76766800dfab17e9b55 https://doi.org/10.1016/j.tet.2008.10.012 Zobrazit plný text záznamu Full Text from ScienceDirect