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Background Geographical variations in genotype and phenotype of Behcet’s syndrome (BS) are reported.1,2 Previous meta-analysis of international cohorts has highlighted differences in clinical manifestations of BS by gender.3 A comparison of BS clinical manifestations by gender has not been analysed previously in a large UK BS cohort. Objectives 1) To compare the clinical manifestations of BS in a UK cohort by gender and 2) to compare this to published international data. Methods A retrospective cross sectional analysis was performed using clinical databases at the Liverpool and Birmingham BS Centres of Excellence. Patients with a multi-disciplinary diagnosis of BS or International Study Group (ISG) diagnostic criteria were included. Clinical manifestations and HLA-B51 positivity were compared by gender. T-tests and chi-squared tests were used for continuous and categorical data respectively and a p value of 0.05 or less was considered statistically significant. Results 433 patients met inclusion criteria (140 males, 32.3%). Male patients were younger and had significantly higher rates of ocular and vascular involvement, papulopustular skin rash and HLA-B51 positivity. Female patients had significantly higher rates of genital aphthosis and arthralgia. Conclusions Similar to published international cohorts, male patients with BS in the UK have higher rates of ocular and venous involvement, papulopustular skin rash and HLA-B51 positivity and lower rates of genital aphthosis and arthralgia in comparison to female patients. However, the extent to which these differences are attributable to ethnicity is unclear. References [1] Leonardo NM, McNeil J. Behcet’s Disease: Is There Geographical Variation? A Review Far from the Silk Road. Int J Rheumatol2015: 1–7. doi:10.1155/2015/945262 [2] Sibley C, Yazici Y, Tascilar K, Khan N, Bata Y, Yazici H, et al. Behcet syndrome manifestations and activity in the United States versus Turkey - a cross-sectional cohort comparison. J Rheumatol2014;41:137984. doi:10.3899/jrheum.131227 [3] Bonitsis NG, Nguyen LBL, LaValley MP, Papoutsis N, Altenburg A, et al. Gender-specific differences in Adamantiades-Behcet’s disease manifestations: an analysis of the German registry and meta-analysis of data from the literature. Rheumatology (Oxford). 2015;54: 121–33. doi:10.1093/rheumatology/keu247 Disclosure of Interest None declared |
