Intraspinal injection of embryonic neurons maintains muscle phenotype in adult chronic spinal rats

Autor:	R.N. Cooper, Didier Orsal, Delphine Feraboli-Lohnherr, G. Butler-Browne, M Giménez y Ribotta, A. Privat
Rok vydání:	1996
Předmět:	Soleus muscle medicine.medical_specialty Hindlimb Anatomy Biology medicine.disease Spinal cord Embryonic stem cell Muscle atrophy Transplantation Cellular and Molecular Neuroscience Atrophy Endocrinology medicine.anatomical_structure Internal medicine Monoaminergic medicine medicine.symptom
Zdroj:	Journal of Neuroscience Research. 46:324-329
ISSN:	1097-4547 0360-4012
DOI:	10.1002/(sici)1097-4547(19961101)46:3<324::aid-jnr5>3.0.co;2-m
Popis:	A suspension of monoaminergic embryonic neurons was transplanted into the spinal cord of paraplegic rats. Enzyme histochemical, morphometric, and biochemical analyses of the hindlimb musculature were carried out 2-5 months later to determine the consequences on muscle atrophy and muscle phenotypes which were compared in three groups of rats: intact, spinalized, and spinalized and transplanted with embryonic cells. Our results indicate that this transplantation does not prevent muscular atrophy, which appears highly dependent on the level of muscular activity, but partially maintains the slow phenotype, especially in the soleus muscle. We conclude that fiber phenotypes are not determined by the level of muscular activity alone but are also dependent on putative trophic factors synthesized by motoneurones.
Databáze:	OpenAIRE
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