Wegener' granulomatosis

Autor: Michael J. Reza, Carl M. Pearson, Rodney Bluestone, Leonard S. Goldberg, Leslie Dornfeld
Rok vydání: 1975
Předmět:
Zdroj: Arthritis & Rheumatism. 18:501-506
ISSN: 1529-0131
0004-3591
DOI: 10.1002/art.1780180513
Popis: Ten patients with Wegener's granulomatosis were treated with cyclophosphamide and followed for periods up to 7 years. In all cases cyclophosphamide induced complete remissions. The mean duration of remission (to date) was 38 months. Six patients have been in remission for a mean of 46 months after cyclophosphamide was discontinued; 2 have been disease-free for 7 years. Of the 10 patients treated, only 1 relapsed and she responded to a second course of cyclophosphamide. These results indicate that cyclophosphamide is the drug of choice in Wegener's granulomatosis. The long-term effectiveness of this drug suggests that it may induce permanent remissions in certain patients with Wegener's granulomatosis.
Databáze: OpenAIRE
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