| Autor: |
Faiyaz Ahmad, Pei-Ming Li, Wendi Ding, Wei-Ren Zhang, Barry J. Goldstein |
| Rok vydání: |
1998 |
| Předmět: |
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| Popis: |
Publisher Summary This chapter reviews specific protein tyrosine phosphatase (PTPase) enzymes that serve to regulate insulin signaling in normal physiology and that these enzymes may be involved in the pathogenesis of cellular insulin resistance in human obesity and type II diabetes. Reversible tyrosine phosphorylation plays an essential role in activation of the insulin receptor kinase as well as at postreceptor sites in the insulin action pathway. Recent studies have shown that cellular PTPase enzymes regulate the steady-state activity of the insulin receptor kinase by dephosphorylating the active (autophosphorylated) form of the insulin receptor. PTPases may also be shown to play a role in insulin receptor regulation in future work. Also, the cellular PTPases that regulate the reversible phosphorylation of IRS-1, IRS-2, and Shc have not been identified. Work in this area will pave the way for the development of agents that can inhibit individual PTPases involved in insulin-resistant states in order to augment insulin signaling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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