H1-MR-spectroscopy of cerebellum in adult attention deficit/hyperactivity disorder

Autor:	Bernd Hesslinger, L. Tebarzt van Elst, M. Buechert, Alexandra Philipsen, Dieter Ebert, Steven F. Maier, Evgeniy Perlov, Swantje Matthies
Rok vydání:	2010
Předmět:	Cerebellum Central nervous system Glutamate receptor Cognition medicine.disease Psychiatry and Mental health medicine.anatomical_structure Neurochemical Cerebellar hemisphere medicine Attention deficit hyperactivity disorder Neurochemistry Psychology Neuroscience Biological Psychiatry
Zdroj:	Journal of Psychiatric Research. 44:938-943
ISSN:	0022-3956
DOI:	10.1016/j.jpsychires.2010.02.016
Popis:	Introduction: Neurobiological research has implicated the cerebellum as one possible site of neurophysiological dysfunction in ADHD. Latest theoretical conceptualizations of the cerebellum as core site of the brain to model motor as well as cognitive behavior puts further weight to the assumption that it might play a key role in ADHD pathophysiology. Methods: 30 medication free adult ADHD patients and 30 group matched (gender, age and education) healthy controls were investigated using the method of chemical shift imaging (CSI) of the cerebellum. The vermis, left and right cerebellar hemispheres were processed separately. Results: We found significantly increased glutamate-glutamine (Glx) to creatine (Cre) ratios in the left cerebellar hemisphere. No other differences in measured metabolite concentrations were observed. Discussion: To our knowledge this is the first evidence for neurochemical alterations in cerebellar neurochemistry in adult ADHD. They relate well to recent hypotheses that the cerebellum might control mental activities by internal models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::11791bf60e5ffbbadf1ac4270ba80138 https://doi.org/10.1016/j.jpsychires.2010.02.016 Zobrazit plný text záznamu Full Text from ScienceDirect