Selective use of calcium channel blockers to treat high-risk hypertensive patients

Autor: Daniel M. Huse, Lewis H. Roht, Stuart C Hartz
Rok vydání: 2000
Předmět:
Zdroj: Pharmacoepidemiology and Drug Safety. 9:1-9
ISSN: 1099-1557
1053-8569
Popis: Purpose While hypertension treatment is aimed at reducing cardiovascular disease (CVD) risk, there are reports of association between calcium channel blockers (CCB) use and increased risk. However, these studies may be misleading if CCBs are used selectively in high-risk patients. Methods We conducted a knowledge, attitudes, and practice (KAP) survey by mail of a stratified random sample of 10,000 US cardiologists, internists, and family/general practitioners. Completed surveys were received from 1023 physicians, and population means and frequencies (±standard errors) were estimated Results While only 36.3 (±0.6)% of physicians use long-acting CCBs for mild hypertension without additional risk factors, use increases with moderate or severe hypertension and other risk factors, including history of myocardial infarction (48.4 (±0.6)%), family history of CVD (54.6 (±0.6)%), diabetes (57.3 (±0.6)%), and angina (63.8 (±0.5)%). Physicians use CCBs as initial therapy for 24.8 (±0.3)% of mildly and 33.1 (±0.3)% of moderately hypertensive patients, and add CCBs to the regimens of 39.0 (±0.3)% of moderately hypertensive patients not controlled on other antihypertensive therapy. In multiple regression analysis, the proportion of hypertensive patients treated with CCBs was significantly elevated among geriatricians and physicians who believe severity of hypertension is an indication for their use. Conclusion These findings suggest that CCBs are used selectively for high-risk hypertensive patients. Copyright © 2000 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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