Isolation and structure determination of lysiformine from bacteria associated with marine sponge Halichondria okadai
| Autor: | Mari Yotsu-Yamashita, Eunsang Kwon, Kayo Okada, Shinichiro Yoshida, Yuko Cho, Keiichi Konoki, Sou Kikuchi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chromatography biology Organic Chemistry Ethyl acetate Brine shrimp Lysinibacillus fusiformis medicine.disease_cause biology.organism_classification Isolation (microbiology) Biochemistry 03 medical and health sciences chemistry.chemical_compound Sponge 030104 developmental biology chemistry Drug Discovery medicine Cytotoxicity Bacteria Halichondria okadai |
| Zdroj: | Tetrahedron. 74:3742-3747 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.05.049 |
| Popis: | Marine sponge Halichondria okadai is a source of numerous toxic secondary metabolites, which are considered as products of the symbiotic species associated with the sponge. In this study, we tested 720 culture conditions and purified 48 sponge-associated microbes. The ethyl acetate extract from the liquid culture of each species was tested for cytotoxicity, hemolytic activity, and brine shrimp lethal activity. Lysiformine (1) was isolated from Lysinibacillus fusiformis and its structure was determined by HRMS and NMR. |
| Databáze: | OpenAIRE |
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