In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography
| Autor: | Dong Jun Shin, Jin-Chul Ahn, Phil-Sang Chung, Hang Chan Jo, DaeYu Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Laser ablation medicine.diagnostic_test business.industry 010401 analytical chemistry High resolution 02 engineering and technology 021001 nanoscience & nanotechnology Laser 01 natural sciences 0104 chemical sciences law.invention Wavelength Optics Optical coherence tomography Laser tissue interaction law In vivo medicine sense organs Nanosecond laser 0210 nano-technology business |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2251558 |
| Popis: | Laser-induced therapies include laser ablation to remove or cut target tissue by irradiating high-power focused laser beam. These laser treatments are widely used tools for minimally invasive surgery and retinal surgical procedures in clinical settings. In this study, we demonstrate laser tissue interaction images of various sample tissues using high resolution Fourier-domain optical coherence tomography (Fd-OCT). We use a Q-switch diode-pumped Nd:YVO4 nanosecond laser (532nm central wavelength) with a 4W maximum output power at a 20 kHz repetition rate to ablate in vitro and in vivo samples including chicken breast and mouse ear tissues. The Fd-OCT system acquires time-series Bscan images at the same location during the tissue ablation experiments with 532nm laser irradiation. The real-time series of OCT cross-sectional (B-scan) images compare structural changes of 532nm laser ablation using same and different laser output powers. Laser tissue ablation is demonstrated by the width and the depth of the tissue ablation from the B-scan images. |
| Databáze: | OpenAIRE |
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