β-L-1,3-Dioxolane-Cytidine:A Novel Nucleoside ThatInhibits Proliferation andInduces Differentiation ofKeratinocytes in vitro

Autor:	Y.-C. Cheng, John G. Haggerty, Pauline M. Schwartz
Rok vydání:	1998
Předmět:	Pharmacology Physiology Cell growth Biological activity Cytidine Dermatology General Medicine Biology In vitro chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry Dioxolane medicine Keratinocyte Cytotoxicity Nucleoside
Zdroj:	Skin Pharmacology and Physiology. 11:207-213
ISSN:	1660-5535 1660-5527
DOI:	10.1159/000029829
Popis:	β-L-1,3-Dioxolane-cytidine (L-(–)-OddC) is a novel L-nucleoside, and its antitumor activity is under investigation in clinical trials. To evaluate the potential of L-(–)-OddC for treating hyperproliferative diseases of the skin, we examined its activity in human keratinocytes in vitro. The dose of L-(–)-OddC that inhibited the rate of proliferation of keratinocytes by 50% was 50 nM. L-(–)-OddC was about as cytotoxic as 9-β-D-arabinofuranosylcytosine but was about 1,000 time more potent than 3′-azidothymidine. L-(–)-OddC caused irreversible growth arrest and induced differentiation of keratinocytes. L-(–)-OddC altered morphology, increased the cell size of keratinocytes and increased the expression of involucrin. These data suggest that L-(–)-OddC may have potential as a therapeutic agent against hyperproliferative skin diseases.
Databáze:	OpenAIRE
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