Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model
| Autor: | Youjin Lee, Uran Ferizi, Oran D. Kennedy, Thorsten Kirsch, Jenny T. Bencardino, Matin Lendhey, Ignacio Rossi, José G. Raya, Jason Teplensky |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Cartilage Biomechanics Knee replacement Histology Magnetic resonance imaging Articular cartilage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Fractional anisotropy Medicine Radiology Nuclear Medicine and imaging Radiology business Diffusion MRI |
| Zdroj: | Magnetic Resonance in Medicine. 78:69-78 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.26336 |
| Popis: | PURPOSE We establish a mechanical injury model for articular cartilage to assess the sensitivity of diffusion tensor imaging (DTI) in detecting cartilage damage early in time. Mechanical injury provides a more realistic model of cartilage degradation compared with commonly used enzymatic degradation. METHODS Nine cartilage-on-bone samples were obtained from patients undergoing knee replacement. The 3 Tesla DTI (0.18 × 0.18 × 1 mm3 ) was performed before, 1 week, and 2 weeks after (zero, mild, and severe) injury, with a clinical radial spin-echo DTI (RAISED) sequence used in our hospital. We performed stress-relaxation tests and used a quasilinear-viscoelastic (QLV) model to characterize cartilage mechanical properties. Serial histology sections were dyed with Safranin-O and given an OARSI grade. We then correlated the changes in DTI parameters with the changes in QLV-parameters and OARSI grades. RESULTS After severe injury the mean diffusivity increased after 1 and 2 weeks, whereas the fractional anisotropy decreased after 2 weeks (P |
| Databáze: | OpenAIRE |
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