| Popis: |
There are very few reports about complete-blood-count (CBC) findings in paediatric tuberculosis. We assessed the prevalence and predictors of haematologic abnormalities and the utility of a routine CBC in initial management of paediatric TB. We reviewed records and results of investigations of all children and adolescents (ages 0–18) treated for TB disease at the Hospital for Sick Children, Toronto, Canada from January 2002 to December 2012. Anaemia was found in 52/138 (42%) patients, was often microcytic, more prevalent in adolescent females (Odds Ratio (OR) 3.7 [95% confidence intervals (CI) 1.27–10.6]) and those with disseminated disease (OR 3.60 [95% CI 1.12–11.53]), and often resolved with anti-tuberculous treatment. Only 4 children received iron therapy. White cell abnormalities that occurred often suggested diagnoses other than TB: lymphopenia occurred in 30/124 patients (24%) (all HIV negative) and neutrophilia in 20/124 (16%) patients, 9 of whom had pulmonary airspace disease. An initial routine CBC seldom changed patient management and had limited utility. |
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