Glucocorticoid receptor in childhood acute lymphoblastic leukemia
| Autor: | Chun-hua Luo, Qing-kui Liao, Ping Yang |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Oncology
Cancer Research Chemotherapy medicine.medical_specialty medicine.medical_treatment Cell Combination chemotherapy Venous blood Biology medicine.disease Leukemia medicine.anatomical_structure Glucocorticoid receptor Internal medicine Immunology medicine Receptor Childhood Acute Lymphoblastic Leukemia |
| Zdroj: | Chinese Journal of Cancer Research. 11:214-217 |
| ISSN: | 1993-0631 1000-9604 |
| DOI: | 10.1007/s11670-999-0015-x |
| Popis: | Objective: To investigate the relationship among glucocorticoid receptor (GCR) level, immunological classification and clinical efficacy of chemotherapy in acute lymphoblastic leukemia (ALL) children. Methods: The GCR level of venous blood lymphocytes was measured by receptor radioligand binding assay in 50 cases with childhood ALL and 41 normal children. The immunological classification of 32 children with ALL was analyzed by ABC immunoenzymatic method. Results: The GCR number in venous blood lymphocytes of normal children was 4651±1617 binding sites/cell. The normal range (95%) was 1482-7800 binding sites/cell. The GCR level of 50 cases with ALL (6695±5256 binding sites/cell) was significantly higher than that of the normal ones (t=2.50, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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