Lithium in Hospitalized Aggressive Children with Conduct Disorder: A Double-Blind and Placebo-Controlled Study
| Autor: | Vivian Kafantaris, Richard Perry, Phillip Adams, John E. Overall, Raul R. Silva, Arthur M. Small, Magda Campbell, Juanita Shell |
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| Rok vydání: | 1995 |
| Předmět: |
Pediatrics
medicine.medical_specialty education.field_of_study Lithium (medication) Population Placebo-controlled study Profile of mood states Placebo medicine.disease law.invention Clinical trial Psychiatry and Mental health Randomized controlled trial law Conduct disorder Developmental and Educational Psychology medicine Psychiatry education Psychology medicine.drug |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 34:445-453 |
| ISSN: | 0890-8567 |
| Popis: | Objective To assess critically the efficacy and safety of lithium and replicate earlier findings in a larger sample of aggressive children with conduct disorder and to assess the utility of the Profile of Mood States (POMS) in this population. Method Children hospitalized for treatment-refractory severe aggressiveness and explosiveness and with diagnosed conduct disorder were subjects in this double-blind, placebo-controlled clinical trial. After a 2-week placebo baseline period, children were randomly assigned to lithium or placebo treatment for 6 weeks followed by 2 weeks of placebo. The main outcome measures were the Global Clinical Judgments (Consensus) Scale, Children's Psychiatric Rating Scale, Conners Teacher Questionnaire, Parent-Teacher Questionnaire, and the POMS. Results Fifty children (mean age 9.4 years) completed this study. The mean optimal dally dose of lithium was 1,248 mg and the mean serum level was 1.12 mEq/L. Lithium was superior to placebo, although the effects on some measures were more modest than in a previous study. Conclusions Lithium appears to be an effective treatment for some severely aggressive children with conduct disorder. Although the POMS appeared to be reliable, it did not detect any response to lithium. |
| Databáze: | OpenAIRE |
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