TCCA/NCS-Promoted Cascade Cyclization of β, γ-Unsaturated Compounds: Synthesis of Isoxazolines and Pyrazolines
Autor: | Nibras Ahmed Elaas, Khidir Tajelseir Othman |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | International Journal of Organic Chemistry. 11:187-198 |
ISSN: | 2161-4695 2161-4687 |
Popis: | 2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with N-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of β, γ-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of β, γ-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, 1H, 13C NMR and Mass spectroscopies. |
Databáze: | OpenAIRE |
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