TCCA/NCS-Promoted Cascade Cyclization of β, γ-Unsaturated Compounds: Synthesis of Isoxazolines and Pyrazolines

Autor:	Nibras Ahmed Elaas, Khidir Tajelseir Othman
Rok vydání:	2021
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Hydrazone General Medicine Trichloroisocyanuric acid Carbon-13 NMR Oxime Medicinal chemistry
Zdroj:	International Journal of Organic Chemistry. 11:187-198
ISSN:	2161-4695 2161-4687
Popis:	2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with N-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of β, γ-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of β, γ-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, 1H, 13C NMR and Mass spectroscopies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::112cd1180ee02cf505a7573459245646 https://doi.org/10.4236/ijoc.2021.114013 Zobrazit plný text záznamu