Separation of the Enantiomers of β-Blockers Using Brush Type Chiral Stationary Phase Derived from Conformationally Rigid α-Amino β-Lactam

Autor:	Wonjae Lee, William H. Pirkle
Rok vydání:	2010
Předmět:	animal structures Resolution (mass spectrometry) Column temperature Stereochemistry fungi Brush General Chemistry Chiral stationary phase complex mixtures Phosphonate law.invention chemistry.chemical_compound chemistry law Phase (matter) parasitic diseases Lactam Enantiomer
Zdroj:	Bulletin of the Korean Chemical Society. 31:620-623
ISSN:	0253-2964
DOI:	10.5012/bkcs.2010.31.03.620
Popis:	A brush type chiral stationary phase (CSP 2) derived from α-amino β-lactam was prepared for the separation of the enan- tiomers of β-blockers. Compared to the CSP derived from α-amino phosphonate (CSP 1), in general, the conforma- tionally rigid CSP 2 showed greater scope and much enhanced enantioselectivity for the resolution of β-blockers. The effect of various salt additives on enantioseparation of β-blockers in the mobile phase was investigated. The unusual effect of temperature on the chromatographic behaviors was observed on CSP 2. It also afforded appreciable increases in enantioselectivity without significantly affecting resolution, as the column temperature was reduced.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::111bc8dc551f49bcd51ff3af8d2e962b https://doi.org/10.5012/bkcs.2010.31.03.620 Zobrazit plný text záznamu