Polyunsaturated Fatty Acids and Cardiovascular Events: A Fish Tale
| Autor: | J. Thomas Bigger, Tarek El-Sherif |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty education.field_of_study business.industry Incidence (epidemiology) Population Adipose tissue medicine.disease Eicosapentaenoic acid Sudden cardiac death Endocrinology chemistry Docosahexaenoic acid Physiology (medical) Internal medicine Epidemiology medicine Cardiology and Cardiovascular Medicine business education Polyunsaturated fatty acid |
| Zdroj: | Circulation. 103:623-625 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | The Eskimo diet has a high fat content, but this group has a low incidence of deaths from coronary heart disease.1 Because the Eskimo diet contains large amounts of long-chain polyunsaturated fatty acids (PUFAs),2 many studies have been conducted to determine whether high dietary PUFAs may reduce death from coronary heart disease. These studies, which have focused on two n-3 PUFAs that are relatively abundant in fish, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), include many prospective epidemiological studies, a few case-control studies, and 2 secondary prevention trials.3 4 5 6 7 8 9 10 11 12 13 Most of the prospective population studies showed a statistically significant inverse relationship between fish consumption and the risk of death from coronary heart disease. The dose-response relationship was complex in these studies: the reduction in coronary risk was greatest when adding a modest amount of dietary fish to populations that previously had low fish intake. Increasing fish intake still more did not incrementally decrease risk. Many of these studies measured n-3 PUFA incorporation into the cell membranes of platelets, granulocytes, adipose tissue, or erythrocytes. Overall, there was a significant correlation between fish intake and the level of n-3 PUFA in cell membranes. The overall consistency in the observational studies is excellent and signals a survival benefit from dietary n-3 PUFA. The epidemiological data suggest that the benefit of dietary fish is centered on a reduction in sudden cardiac death. A case-control study in Seattle compared 334 victims of out-of-hospital primary cardiac arrest with 493 population-based controls.11 Compared with no dietary intake of EPA, ≥5.5 g of n-3 PUFA per month was associated with a 50% decrease in the risk of primary cardiac arrest. The US Physician’s Health Study studied the effect of dietary fish on sudden cardiac death … |
| Databáze: | OpenAIRE |
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