Initial design and physical characterization of a polymeric device for osmosis-driven delayed burst delivery of vaccines
| Autor: | Ingo Fehr, Tim R. Dargaville, Kenneth W. Beagley, Dietmar W. Hutmacher, Ferry P.W. Melchels, Annika S. Reitz, Urip Dunker |
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| Rok vydání: | 2015 |
| Předmět: |
0303 health sciences
Bioengineering Nanotechnology 02 engineering and technology Vaccine delivery Polyethylene glycol 021001 nanoscience & nanotechnology Osmosis Applied Microbiology and Biotechnology Biodegradable polymer 3. Good health Polyester 03 medical and health sciences chemistry.chemical_compound chemistry Drug delivery Copolymer 0210 nano-technology Caprolactone 030304 developmental biology Biotechnology Biomedical engineering |
| Zdroj: | Biotechnology and Bioengineering. 112:1927-1935 |
| ISSN: | 0006-3592 |
| DOI: | 10.1002/bit.25593 |
| Popis: | Achieving the combination of delayed and immediate release of a vaccine from a delivery device without applying external triggers remains elusive in implementing single administration vaccination strategies. Here a means of vaccine delivery is presented, which exploits osmosis to trigger delayed burst release of an active compound. Poly(e-caprolactone) capsules of 2 mm diameter were prepared by dip-coating, and their burst pressure and release characteristics were evaluated. Burst pressures (in bar) increased with wall thickness (t in mm) following Pburst = 131(.) t + 3(.) 4 (R(2) = 0.93). Upon immersion in PBS, glucose solution-filled capsules burst after 8.7 ± 2.9 days. Copolymers of hydrophobic e -caprolactone and hydrophilic polyethylene glycol were synthesized and their physico-chemical properties were assessed. With increasing hydrophilic content, the copolymer capsules showed increased water uptake rates and maximum weight increase, while the burst release was earlier: 5.6 ± 2.0 days and 1.9 ± 0.2 days for 5 and 10 wt% polyethylene glycol, respectively. The presented approach enables the reproducible preparation of capsules with high versatility in materials and properties, while these vaccine delivery vehicles can be prepared separately from, and independently of the active compound. |
| Databáze: | OpenAIRE |
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