Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes
| Autor: | Juan A. Ardura, Arancha R. Gortazar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glycation Diabetes mellitus Internal medicine medicine Secretion biology business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry RANKL Osteocyte biology.protein Sclerostin business Intracellular Function (biology) |
| Zdroj: | Current Osteoporosis Reports. 18:796-802 |
| ISSN: | 1544-2241 1544-1873 |
| Popis: | Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state—based on hyperglycemia and accumulation of advanced glycation end products among other features—impairs osteocyte functions exerting deleterious effects on bone. In the last years, several studies described that diabetic conditions cause morphological modifications on lacunar-canalicular system, alterations on osteocyte mechanoreceptors and intracellular pathways and on osteocyte communication with other cells through the secretion of proteins such as sclerostin or RANKL. This article gives an overview of events occurring in diabetic osteocytes. In particular, mechanical responses seem to be seriously affected in these conditions, suggesting that mechanical sensibility could be a target for future research in the field. |
| Databáze: | OpenAIRE |
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