Functional impairment of CMV-reactive cellular immunity during pregnancy
| Autor: | Hanna Bendfeldt, Ludwig Deml, Birgit Seelbach-Goebel, Florian Zeman, Anne Rascle, Sascha Barabas, E Reuschel |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cellular immunity Pregnancy biology business.industry ELISPOT virus diseases medicine.disease Virology Immune tolerance 03 medical and health sciences 030104 developmental biology Infectious Diseases Immune system Immunoglobulin M Immunology medicine biology.protein Young adult Serostatus business |
| Zdroj: | Journal of Medical Virology. 89:324-331 |
| ISSN: | 0146-6615 |
| DOI: | 10.1002/jmv.24639 |
| Popis: | Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to-child transmission can cause severe child disability. Intact CMV-specific cell-mediated immunity (CMI) was shown to prevent uncontrolled replication in healthy individuals. This study aimed to determine whether CMV-specific CMI is impaired in pregnant women, thus potentially increasing the overall risk for active CMV replication and transmission. CMV-specific CMI in peripheral blood of 60 pregnant women was determined using T-Track® CMV for detection of IE-1 and pp65-reactive effector cells by IFN-γ ELISpot, and compared to the CMV-IgG and -IgM serostatus. CMV-specific CMI was detected in 65% of CMV-seropositive pregnant women. Five percent of CMV-IgG seronegative women showed IE-1- but not pp65-reactive cells. The overall number of CMV-reactive cells in pregnant women was significantly lower compared to a matched non-pregnant control group (P |
| Databáze: | OpenAIRE |
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