A novel Mn(II) complex with 3-(2,5-dicarboxyl)-5-carboxylpyridine: Synthesis, crystal structure, and interaction with DNA

Autor:	En-Jun Gao, Xiao-Yu Ma, Mingchang Zhu, Chi Ma, Shi-Kai Liang, Fu-Chen Zhao, Hai-Tao Jin, Yang Meng
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Gel electrophoresis Coordination polymer General Chemical Engineering Infrared spectroscopy General Chemistry Polymer Crystal structure Fluorescence chemistry.chemical_compound Crystallography chemistry Cleave DNA
Zdroj:	Russian Journal of Coordination Chemistry. 41:599-606
ISSN:	1608-3318 1070-3284
DOI:	10.1134/s107032841509002x
Popis:	A novel Mn coordination polymer, {[Mn2(L)6] · 2H2O}n, has been synthesized by the reaction of C4H6MnO4 · 4H2O (manganese acetate) with 3-(2,5-dicarboxyl)-5-carboxylpyridine (L). Elemental analysis, IR spectra, thermal analyses, and X-ray single crystal diffraction (CIF file CCDC no. 1061752) were carried out to determine the composition and crystal structure of the complex. The polymer was characterized by UV spectrum, fluorescence spectrum showing that the complex has the ability of interaction with DNA, Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA (HL-60 DNA, which was extracted by ourselves). Further more, the apoptotic test indicates that the complex has an apoptotic effect on JEKO.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10fef079a1964bdf5e2702ae4f3f963c https://doi.org/10.1134/s107032841509002x Zobrazit plný text záznamu Full text from SpringerLink