Spontaneous Hypercholesterolemia in Pigs
| Autor: | Scott T. Cooper, R.J. Aiello, Patricia J. Uelmen, Alan D. Attie |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Apob gene Population nutritional and metabolic diseases Locus (genetics) Biology Heritability Endocrinology Plasma cholesterol Internal medicine LDL receptor Cholesterylester transfer protein medicine biology.protein lipids (amino acids peptides and proteins) education Gene |
| Zdroj: | Human Apolipoprotein Mutants III ISBN: 9783642846366 |
| DOI: | 10.1007/978-3-642-84634-2_10 |
| Popis: | Genetic factors contribute approximately 50% to the variability in plasma cholesterol. The best-characterized cholesterol-elevating mutations are those of the LDL receptor locus. Together, these mutations account for approximately 1% of the incidence of hypercholesterolemia in the human population. Since the estimated heritability coefficient for hypercholesterolemia is approximately 0.5, the quest is on to identify other gene loci that contribute to hypercholesterolemia. |
| Databáze: | OpenAIRE |
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