Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children
| Autor: | Aírton Viriato, Marcello Ruiz da Silva, Rodrigo Strehl Machado |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Doxycycline
medicine.medical_specialty Abdominal pain biology Furazolidone business.industry Nausea Rapid urease test Helicobacter pylori biology.organism_classification Gastroenterology Surgery Internal medicine Pediatrics Perinatology and Child Health Vomiting Medicine medicine.symptom business Omeprazole medicine.drug |
| Zdroj: | Jornal de Pediatria. 84:160-165 |
| ISSN: | 0021-7557 |
| DOI: | 10.2223/jped.1772 |
| Popis: | Objectives: To evaluate furazolidone, tetracycline and omeprazole as first line therapy for Helicobacter pylori in children with digestive symptoms. Methods: Prospective and consecutive open trial. The study included patients older than 8 years old with functional dyspepsia, functional abdominal pain, severe histological abnormalities (intestinal metaplasia, gastric atrophy or mucosa-associated lymphoid tissue lymphoma) or peptic ulcer. H. pylori status was defined based both upon histology and rapid urease test. Drug regimen was a 7-day course of omeprazol, tetracycline (or doxycycline) and furazolidone twice daily. Eradication was assessed by upper endoscopy 2 months after treatment (histology and rapid urease test). Further clinical evaluation was done 7 days and 2 months after treatment. Results: Thirty-six patients (21 female/15 male) were included. Age ranged from 8 to 19 years (mean 12.94±2.89 years). On intention-to-treat analysis (n = 36), eradication rate was 83.3% (95%CI 77.1-89.5) whereas in per-protocol analysis (n = 29), it was 89.7% (95%CI 84.6-94.7). Compliance was better when doxycycline was used, but the success rates were similar for the two tetracyclines. There was no variable associated with treatment failure. Side effects were reported in 17 patients (47.2%), mainly abdominal pain (11/30.5%), nausea (seven/19.4%) and vomiting (five/ 13.9%). |
| Databáze: | OpenAIRE |
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