| Autor: |
Charles L. Mendenhall, Antonio Chedid, Polito Aj, Susan D. Rouster, Gary A. Roselle, Quan S, Thomas E. Moritz |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Gastroenterologia Japonica. 28:95-100 |
| ISSN: |
0435-1339 |
| DOI: |
10.1007/bf02989216 |
| Popis: |
From 8 Department of Veterans Affairs Medical Centers, 296 patients with varying degrees of alcoholic liver disease were tested for hepatitis C (HCV) infection using an EIA and RIBA 2. A high frequency of positive response was observed with 13.9% reactive to both and an additional 4.4% positive only to RIBA 2 (total 18.3%). An evaluation of known risk factors (injection drug use and prior blood transfusions) failed to account for the mode of transmission in 42.6% of the HCV+ patients. The clinical severity of the liver disease and degree of liver pathology were nearly identical in HCV+ vs. HCV- patients. However, the process was accelerated in the HCV+ patients occurring at a 12.8% younger age (p< 0.0001) with a 43% increase in ALT (p=0.05). The most striking differences were observed in immune parameters. In peripheral blood, total lymphocyte counts were increased 20% (p=0.01) accompanied by a 56% increase in B cells (p=0.01) and a 35% elevation of IgG levels (p=0.0001) in HCV+ patients. T cell changes consisted of a 50% increase in CD8 cells (p=0.047). However, lymphocyte infiltration into liver was not significantly different (HCV+ vs. HCV−) for any of the subsets studied (CD4, CD8, B cells, NK cells). The combined presence of HCV and alcohol injury did not significantly increase mortality but did significantly increase the number of hospitalizations from 2.4 to 4.0 per year (p= 0.0005). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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