| Autor: |
Aishatu L Adamu, J. Ojal, Isa A. Abubakar, Kofo Odeyemi, Musa M. Bello, Christy A.N. Okoromah, Boniface Karia, Angela Karani, Donald. Akech, Victor Inem, J. Anthony G Scott, Ifedayo M.O. Adetifa |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.03.11.22271682 |
| Popis: |
BackgroundPneumococcal Conjugate Vaccines (PCVs) reduce the burden of pneumococcal disease by reducing nasopharyngeal acquisition and transmission of serotypes in the vaccines (vaccine-serotypes). Following introduction of the 10-valent PCV (PCV10) in Nigeria, we assessed the population-level impact of PCV introduction on pneumococcal carriage.MethodsWe conducted annual cross-sectional carriage and vaccination coverage surveys between 2016 and 2020 in rural and urban sites in Nigeria. We recruited a random sample of residents and used WHO-recommended laboratory methods to identify pneumococcal serotypes. We modelled prevalence ratios for the change in annual carriage prevalence using log-binomial regression, and explored the association between vaccination coverage in children FindingsWe enrolled 4,684 and 3,653 participants for the carriage surveys and 2,135 and 1,106 children for the coverage surveys in the rural and urban sites, respectively. Carriage prevalence of vaccine-serotypes declined steadily with increasing levels of PCV10 coverage among children aged ConclusionsWe found significant reduction in vaccine-serotype carriage at a population level following a steady increase in PCV10 coverage, indicating direct and indirect vaccine effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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