Gène de l’érythropoïétine : régulation et intérêt thérapeutique

Autor:	Y. Beuzard, P. Rouyer-Fessard, Bruno Dalle, A. Henri
Rok vydání:	1997
Předmět:	Reporter gene Messenger RNA Transgene Hematology Hypoxia (medical) Gene delivery Biology Cell biology Transcription (biology) Erythropoietin medicine medicine.symptom Gene medicine.drug
Zdroj:	Hematology and Cell Therapy. 39:109-113
ISSN:	1279-8509 1269-3286
DOI:	10.1007/s00282-997-0109-1
Popis:	The erythropoietin (Epo) is a model of proteins expressed upon hypoxia, regulated at the transcriptional and post transcriptional levels. The Hypoxia Induced Factor (HIF-I) activates the transcription of genes which exhibit the Hypoxia Regulatory Element (HRE). In addition the mRNA is stabilized upon hypoxia, increasing the hormone synthesis. The Epo gene is a convenient reporter gene to develop gene delivery systems and the in vivo regulation of the transgene. The beta thalassemia and acquired chronic anemias may benefit from the Epo gene transfer and expression, if it becomes safe, tunable and inexpensive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10dc1cd683ba17fb334a6570e80f3049 https://doi.org/10.1007/s00282-997-0109-1 Zobrazit plný text záznamu Full text from SpringerLink