Micellization of Hydrophobically Modified Cyclodextrins. 1. Micellar Structure

Autor:	Florence Djedaini-Pilard, and B. Perly, Th. Zemb, Rachel Auzély-Velty, S. Désert
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Aqueous solution Aggregation number Cyclodextrin Chemistry Dispersity Surfaces and Interfaces Condensed Matter Physics Combinatorial chemistry Micelle Amphiphile Electrochemistry Molecule Organic chemistry General Materials Science Solubility Spectroscopy
Zdroj:	Langmuir. 16:3727-3734
ISSN:	1520-5827 0743-7463
Popis:	The grafting of a cholesterol derivative onto a methylated cyclodextrin through a spacer arm produces an amphiphilic compound exhibiting high solubility in water. This new molecule was fully characterized in terms of chemical and optical purities by high resolution NMR and mass spectrometry. An analysis of its behavior in aqueous solution using surface tension measurements and light, small-angle X-ray, and neutron scattering techniques proved that it self-assembles into monodisperse spherical micelles with an average aggregation number of 24. The micelles can be described as two-shell objects, the cyclodextrin moieties being exposed to the aqueous medium, making them prone to include guest molecules in the cavities. These objects can therefore be of high interest for the targeting of biologically important molecules and especially for the delivery of drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10d899d8a6b15c5344618aa2a5773930 https://doi.org/10.1021/la991361z Zobrazit plný text záznamu