Stability of nonsteroidal anti-inflammatory drugs in urine and solution: effects of degradation on analytical assessment

Autor:	Eylem Funda Göktaş, Erol Kabil
Rok vydání:	2023
Předmět:	Medical Laboratory Technology Clinical Biochemistry General Medicine General Pharmacology Toxicology and Pharmaceutics Analytical Chemistry
Zdroj:	Bioanalysis. 15:407-419
ISSN:	1757-6199 1757-6180
DOI:	10.4155/bio-2023-0029
Popis:	Aims: Knowledge of optimal storage conditions of drugs is crucial for properly interpreting analytical assessments. Materials & methods: The current study aimed to investigate the stability of some nonsteroidal anti-inflammatory drugs using a validated method by gas chromatography (GC)–MS. For this propose, long-term, short-term and solution stability were investigated. Results: The analytes remained stable in the sample, similar to the working solution. The most affected substance over time in both matrix and working solution was phenylbutazone. The freeze–thaw cycle affected flunixin and carprofen, but diclofenac and vedaprofen changed only in the third cycle. In short-term stability, high-temperature conditions changed carprofen. Conclusion: The present study is a comprehensive assay for nonsteroidal anti-inflammatory drug stability and can be used as a reference for results assessment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10cf34b8ee9ebb1b8e5da2b38f0b2ebe https://doi.org/10.4155/bio-2023-0029 Zobrazit plný text záznamu