Intra vitam lumbar and post mortem ventricular cerebrospinal fluid immunoreactive interleukin-6 in Alzheimer's disease patients
| Autor: | Kurt A. Jellinger, I Wichart, Norbert Rösler |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry medicine.medical_treatment General Medicine Disease medicine.disease Central nervous system disease Cerebrospinal fluid Cytokine Lumbar Degenerative disease Neurology medicine biology.protein Neurology (clinical) Alzheimer's disease business Interleukin 6 |
| Zdroj: | Acta Neurologica Scandinavica. 103:126-130 |
| ISSN: | 0001-6314 |
| DOI: | 10.1034/j.1600-0404.2001.103002126.x |
| Popis: | Objectives In view of contradictory findings in previous studies, to examine the diagnostic value of interleukin-6 measurements in cerebrospinal fluid (CSF) of Alzheimer's disease patients. Material and methods Interleukin-6-immunoreactivity (IL-6-IR) was measured in 169 intra vitam lumbar and 21 post mortem ventricular CSF samples of patients with probable and neuropathologically confirmed Alzheimer's disease (AD), non-AD dementias (NAD), neurological disorders without cognitive impairment (OND) and controls (CON) using a specific sandwich enzyme immunoassay. Results Intra vitam lumbar samples had significantly elevated (P 65 years) had slightly (P > 0.05) higher values than patients with early onset ( 0.05). Conclusion We conclude that elevations of CSF IL-6-IR can not serve as a diagnostic marker of the disease, but, hypothetically, could reflect presence or activity of IL-6 mediated immunological phenomena in single AD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|