Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model
| Autor: | Takeshi Matsumoto, Hisashi Naito, Masao Tanaka, Toshihiro Sera, Ryosuke Higashi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fluid Flow and Transfer Processes Materials science Terminal velocity Mechanical Engineering Reynolds number Nanoparticle Nanotechnology Sedimentation Condensed Matter Physics 03 medical and health sciences symbols.namesake 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Acinus Volume (thermodynamics) medicine symbols Biophysics Particle 030217 neurology & neurosurgery Particle deposition |
| Zdroj: | International Journal of Heat and Mass Transfer. 108:730-739 |
| ISSN: | 0017-9310 |
| Popis: | We quantitatively investigated nanoparticle deposition (density: 1.0 g/cm3, diameter: 0.1–1.0 μm) in a pulmonary acinus using computational fluid dynamics. We assumed that acinar flow was induced by the expansion and contraction of the acinar model, with the volume changing sinusoidally with time as the boundary condition. We based the complicated acinar model and volume change on a mammalian lung, and evaluated the distribution of particle depositions through acinar generation based on three dimensional thinning. The maximum Reynolds numbers at the inlet and terminal alveoli were 0.191 and 1.93 × 10−3, respectively. With only gravitational force, particle deposition was strongly affected, except for the 0.1- and 0.2-μm particles, and the 0.8- and 1.0-μm particles were deposited around the inlet due to sedimentation after the beginning of inflation. We found that the 0.1- to 0.4-μm particles were deposited at the distal alveoli and that the deposition was enhanced by both the gravitational and Brownian forces, despite the small terminal velocity. For the 0.1- and 0.2-μm particles in particular, the particles were deposited throughout the acinus. The maximum deposition fraction of each acinar segment reached 1.2% after a single breath, and was higher in the middle generations and at the terminal alveoli. |
| Databáze: | OpenAIRE |
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