| Autor: |
Jun R. Huh, Edward J. Usherwood, Hyun Mu Shin, Jason A. Hall, Leslie J. Berg, Andrea Reboldi, Soyoung Ha, Hyoung-Soo Cho |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
ImmunoHorizons. 4:57-71 |
| ISSN: |
2573-7732 |
| Popis: |
The Tec kinase IL-2–inducible T cell kinase (ITK) regulates the expression of TCR-induced genes. Itk−/− T cell responses are impaired but not absent. ITK inhibition prevented colitis disease progression and impaired T cell migration to the colon in mice. To examine the function of ITK in T cell migration to the intestine, we examined the number of gut T cells in Itk−/− mice and then evaluated their expression of gut-homing receptors. Combined with in vitro murine T cell stimulation and in vivo migration assay using congenic B6 mice, we demonstrated an essential role for ITK in T cell migration to the intestine in mice. Reconstitution of Itk−/− mouse CD8+ T cells with IFN regulatory factor 4 restored gut-homing properties, providing mechanistic insight into the function of ITK-mediated signaling in CD8+ T cell migration to the intestinal mucosa in mice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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