A Solitary Necrotizing Sarcoid Granulomatosis-like Pulmonary Lesion Possibly Associated with Propionibacterium acnes and Mycobacterium avium
| Autor: | Kazuhiro Murakami, Toshiharu Tabata, Motoki Kubota, Keisuke Uchida, Keigo Murakami, Yoshinobu Eishi, Naoya Ishibashi, Shuko Hata, Yasuhiro Nakamura |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Solitary pulmonary nodule Lung biology business.industry General Medicine medicine.disease biology.organism_classification Pathophysiology Lesion Propionibacterium acnes medicine.anatomical_structure Coagulative necrosis hemic and lymphatic diseases Internal Medicine Coinfection medicine Sarcoidosis medicine.symptom business |
| Zdroj: | Internal Medicine. 60:3773-3778 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.7162-21 |
| Popis: | We report a case of a pulmonary necrotizing sarcoid granulomatosis (NSG)-like lesion possibly associated with coinfection of Mycobacterium avium and Propionibacterium acnes. A solitary nodule in the right middle lobe of the lung was notable for coagulative necrosis with aggregates of sarcoid-like epithelioid granulomas. Small arteries were damaged by granulomas. Both M. avium and P. acnes were detected in the lesion. Furthermore, more P. acnes genomes were detected in the granulomas than in the non-lesion lung. These findings blur the pathophysiologic boundaries among NSG, sarcoidosis, and mycobacteriosis, and suggest that NSG needs to be recognized as continuous spectra of sarcoidosis/mycobcteriosis. |
| Databáze: | OpenAIRE |
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