КІЛЬКІСНЕ ВИЗНАЧЕННЯ L-ТРИПТОФАНУ ТА ТІОТРИАЗОЛІНУ В МОДЕЛЬНІЙ СУМІШІ
| Autor: | O. O. Portna, L. I. Kucherenko, S. O. Borsuk, І. А. Мazur |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Фармацевтичний часопис. |
| ISSN: | 2414-9926 2312-0967 |
| DOI: | 10.11603/2312-0967.2018.2.9002 |
| Popis: | The aim of work. To develop standardization methods the model mixture, which consists of L-tryptophan and thiotriazoline in the therapeutic ratio 4:1.Materials and Methods. During the study, 6 series of the model mixture of L-tryptophan and thiotriazoline in a ratio of 4:1 (the active ingredient content per tablet 200 mg and 50 mg respectively) were prepared in the laboratory and was developed the standardization method for their simultaneous determination by HPLC.Results and Discussion. An analysis of 6 series of a model mixture (in each of 6 experiments) was carried out according to the developed HPLC method. As a result of the study, we have determined the content of L-tryptophan, which is from 197.2 mg to 204.9 mg, thiotriazoline from 48.9 mg to 50.5 mg, that meets the requirements of the current normative documentation.Results. In the course of work, we have developed a high-sensitivity, reproducible, reliable, high-precision method of simultaneous standardization of active substances, which is planned to be used for the stage-by-stage control of the quality of L-tryptophan and thiotriazoline tablets. |
| Databáze: | OpenAIRE |
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