ChemInform Abstract: Chemoselective Fluorination of 2-Hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones Using DAST

Autor:	Liliane M. F. Porte, Carson W. Whietan, Lenon M. Oliveira, Fábio M. Luz, Jussara Navarini, Marcos A. P. Martins, Helio G. Bonacorso, Gisele R. Paim, Nilo Zanatta
Rok vydání:	2011
Předmět:	Diethylaminosulfur trifluoride chemistry.chemical_compound Trifluoromethyl chemistry Yield (chemistry) Organic chemistry Halogenation General Medicine
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201142136
Popis:	In this study, diethylaminosulfur trifluoride (DAST) was successfully applied in monofluorination reactions of some trifluoromethyl substituted 2-hydroxy-2H-chromenones, employing a general, mild, and efficient methodology. The fluorinated compounds (2-fluoro-2H-chromenones) were synthesized as unique products by a chemoselective reaction in 63–81% yield despite the presence of different reactive sites subjected to reactions with DAST.
Databáze:	OpenAIRE
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