Genetic association of ARID5B with the risk of colorectal cancer within Jammu and Kashmir, India

Autor:	Audesh Bhat, Divya Bakshi, Rajeshwer Singh Jamwal, Amrita Bhat, Ruchi Shah, Sonali Verma, S. P. Singh, Shabab Angurana, Gh. Rasool Bhat, Rakesh Kumar, Samantha Vaishnavi, Bhanu Sharma, Mukesh Tanwar
Rok vydání:	2021
Předmět:	Oncology medicine.medical_specialty education.field_of_study Colorectal cancer Population Cancer Single-nucleotide polymorphism General Medicine Odds ratio Biology medicine.disease Internal medicine Genetics medicine Allele education Molecular Biology Genotyping Genetic association
Zdroj:	Genes & Genetic Systems. 96:187-191
ISSN:	1880-5779 1341-7568
Popis:	Colorectal cancer (CRC), which includes the development of cancer from the colon or rectum, is one of the highly prevalent cancers in the populations of Jammu and Kashmir (J&K) in India. However, case-control genetic association studies on CRC are lacking in this population. Various genome-wide association studies have previously shown that single-nucleotide polymorphisms (SNPs) of the AT-rich interaction domain 5B (ARID5B) gene located on chromosome 10q21.2 contribute substantially to the development of colorectal cancer. The association between ARID5B and CRC risk in north Indian population groups is still unknown. To understand the role of ARID5B SNPs in CRC in the population of J&K, we designed a case-control study to investigate the association of the cancer susceptibility variant rs10740055 of ARID5B with CRC in the population of J&K. The study included 180 cases and 390 healthy controls. Genotyping of the rs10740055 variant was performed by RT-PCR using the TaqMan assay technique. Hardy-Weinberg equilibrium of the variant was assessed using the chi-squared test. The allele- and genotype-specific risks were estimated by odds ratios (ORs) with 95% confidence intervals (CIs). The rs10740055 variant showed a higher risk for colorectal cancer with an OR of 3.35 (1.99-5.65 at 95% CI) and P = 0.000005 corrected for age, gender, ethnicity, BMI, alcohol intake and smoking. Our results indicate that the A allele of rs10740055 imparts risk to the population and also that a larger sample size is needed for further statistical validation. The association of other variants in other ARID family genes should also be tested as their role cannot be ruled out.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1099453d07ea0d1a149da20e684c7825 https://doi.org/10.1266/ggs.21-00010 Zobrazit plný text záznamu